Non sedating muscle
In patients with muscle spasms caused by musculoskeletal conditions, there is not enough evidence to judge whether one skeletal relaxant is safer than another.
It may also reduce pain in patients by inhibiting the release of substance P in the spinal cord, as well.
Consequently, the implications have more to do with genetic counseling and awareness of the condition.Tizanidine appears to be associated with asymptomatic , reversible elevations of aminotransferases, and both tizanidine and chlorzoxazone have been associated with rare cases of serious hepatotoxicity.In majority of cases, long-term use of muscle relaxants for chronic back pain is not recommended due to their high side effect profile unless there is ongoing benefit without significant side effects.Abrupt withdrawal of baclofen can cause seizures, respiratory depression, and delirium that may require ICU admission.
Anaphylactic reactions to NDMRs may be difficult to diagnose, but clinical signs include flushing, hypotension, tachycardia, and bronchospasm following administration of the agent.Muscle spasms can be caused by musculoskeletal conditions, such as back pain and neck pain , or neurological conditions associated with upper motor neuron lesions , such as multiple sclerosis.